Familial inappropriate sinus tachycardia: a new chapter in the story of Hcn4 channelopathies
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چکیده
منابع مشابه
Familial inappropriate sinus tachycardia: a new chapter in the story of HCN4 channelopathies.
The sinoatrial node (SAN) contains a small number of pacemaker cells (PCs), specialized cardiomyocytes whose automatic firing triggers each heart beat. Autonomic and endocrine modulation of PC automaticity enables precise neurohormonal regulation of heart rate (HR) in accordance with physiological demand. While the cellular mechanisms that underlie HR regulation are complex and still actively d...
متن کاملAblation of Inappropriate Sinus Tachycardia
RESULTS A total of 153 patients were included. Their mean age was 35.18 10.02 years, and 139 (90.8%) were female. All patients had failed to respond to maximum tolerated doses of pharmacological therapy (3.5 2.4 drugs). Mean baseline heart rates averaged 101.3 16.4 beats/min according to electrocardiography and 104.5 13.5 beats/min according to 24-h Holter monitoring. Two electrophysiological s...
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Inappropriate sinus tachycardia (IST) is an incompletely understood condition, characterised by an elevation in heart rate (HR) accompanied by wide ranging symptoms in the absence of an underlying physiological stimulus. The condition often takes a chronic course with significant adverse effects on quality of life. Currently, there is no effective treatment for IST. Beta-blockers, generally con...
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Inappropriate sinus tachycardia (IST) is a poorly understood dysrhythmia characterized by palpitations and activity intolerance with an elevated daytime heart rate, exaggerated heart rate response to exercise, and otherwise normal cardiac structure and function. First described in 1979, the disorder is most commonly diagnosed in young women but is not limited to that population (1,2). In additi...
متن کاملPostural Tachycardia Syndrome and Inappropriate Sinus Tachycardia: Role of Autonomic Modulation and Sinus Node Automaticity
BACKGROUND Inappropriate sinus tachycardia (IST) and postural tachycardia syndrome (POTS) are 2 disorders characterized by sinus tachycardia. It is debated whether the pathophysiology of IST and POTS results from abnormal autonomic regulation or abnormal sinus node function. We hypothesized that intrinsic heart rate (IHR) after autonomic blockade would be increased in patients with IST but not ...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2015
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehv635